which outcome in chronic kidney disease-mineral and bone disorder patients?
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Which Outcome in Chronic Kidney Disease-Mineral and Bone Disorder Patients?
Secondary hyperparathyroidism (SHPT) is one the major complications in dialysis patients. Hyperphosphatemia, hypocalcemia, low serum vitamin D levels are greatly involved into the physiopathology of SHPT in chronic kidney disease (CKD), in which the down-regulation of parathyroid Vitamin D Receptor (VDR) and Calcium Sensing Receptor (CaSR) represent a critical step. Moreover, new data demonstra...
متن کاملChronic Kidney Disease-Mineral and Bone Disorder
1Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan 2Centre for Nephrology & Urology, Department of Physiology, Shenzhen University Health Science Center, Shenzhen, China 3Centre for Nephrology, University College London, London, UK 4Centre for Cardiovascular Science, Queen’s Medical Re...
متن کاملChronic kidney disease-mineral and bone disorder KDIGO guidelines.
• one measure of the skeletal component of the systemic disorder of CKD-MBD that is quantifiable by histomorphometry of bone biopsy. The guidelines themselves focussed on three key domains relating to: (1) diagnosis of CKD-MBD with respect to biochemical abnormalities, bone and vascular calcification, 2009 saw the publication of the clinical practice guidelines from Kidney Disease Improving Glo...
متن کاملChronic kidney disease--mineral and bone disorder: a complex scenario.
The chronic kidney disease-bone and mineral disorders (CKD-MBD) represents a dinamic area of research. Recently, new factors such as FGF-23 have been added to the classic list of regulators of bone metabolism, which include calcium, phosphorus, PTH and calcitriol. Vascular calcification, one of the most important complication of CKD-MBD is regulated by a complex variety of promoters and i...
متن کامل[Chronic kidney disease-mineral and bone disorder (CKD-MBD)].
Changes in mineral and bone metabolism are prevalent in chronic kidney disease. There are several types of renal bone disease, called 'renal osteodystrophy (ROD)'. ROD includes osteitis fibrosa, osteomalacia, adynamic bone disorder, and mixed osteodystrophy. Osteitis fibrosa is high turnover bone due to secondary hyperparathyroidism. Osteomalacia is low turnover bone concomitant of increased os...
متن کاملChronic Kidney Disease-Mineral and Bone Disorder: Review
Background: Membrane αKlotho (hereinafter called Klotho) is highly expressed in the kidney and functions as a coreceptor of FGF receptors (FGFRs) to activate specific fibroblast growth factor 23 (FGF23) signal pathway. FGF23 is produced in bones and participates in the maintenance of mineral homeostasis. The extracellular domain of transmembrane Klotho can be cleaved by secretases and released ...
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عنوان ژورنال:
nephro-urology monthlyجلد ۶، شماره ۳، صفحات ۰-۰
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